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KMID : 0922220130130020049
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Journal of the Korean Musculoskeletal Transplantation Society
2013 Volume.13 No. 2 p.49 ~ p.57
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Sterilization Characteristics of Ionizing Irradiation and Its Industrial Application
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Kim Jae-Kyung
Song Beom-Seok
Kim Jae-Hun
Park Jong-Heum
Byun Eui-Baek
Lee Ju-Woon
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Abstract
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Irradiation with ionizing energy such as gamma ray, electron beam and X-ray is cold sterilization/ disinfestation technique applied to full packed products without increase of temperature and any toxic residues. These sterilization events occurred through the direct effect and indirect effect of irradiation to DNA damage and changes of cell components such as proteins and lipids. Radiation sensitivity of the organisms increase when the temperature, contents of oxygen, and water activity are high, which indicates the microorganisms can easily disinfect using irradiation with warm, air and wet condition. Ionizing irradiation has been used to increase storage period of food resources by delaying maturity and control germination/uprooting of agriculture products, disinfestation of harmful bacteria and the pest. Recently, new application of irradiation has been studied to develop special purposed food such as space food, emergency food and patient food. Irradiation also treated to sterilization of public health products includes medical supplies and quarantine or phytosanitary between countries as alternative sterilization methods of chemical preservatives and fumigant. In regenerative medicine fields, ISO recommends using gamma irradiation to eliminate pathogenic microorganisms and assure the safety of allograft. In addition, many research will conduct using ionizing irradiation to decrease immune rejection response and sterilization of xenograft and its industrial need may improve.
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KEYWORD
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Irradiation, Sterilization, Regenerative medicine
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